Integration platform for lipid nanoparticle (LNP) production and characterization

Introduction:
For more than 5 years, our team is working on lipid nanoparticle (LNP) formation mechanisms and on the efficient production of control-sized liposomes. We investigated the formation of LNPs in periodic disturbance microfluidic mixers (PDM) and related specific parameters of the process (Flow rates, temperature, type of solvent, type of lipids) to control the characteristics (size, polydispersity, and zeta potential) of LNPs. We also examined the stability and toxicity of the LNPs in conjunction with the process and the preservation of the specimens.
Objectives:
To investigate the synthesis and formation of lipid nano particles (LNP) in microfluidic mixers related to specific parameters of the process to control their characteristics (size, polydispersity, zeta potential, toxicity, and stability). To create a reliable LNP synthesis platform, capable of producing LNPs at high rates for medical and research applications providing specific size LNPs for drug delivery selectively applied to targeted malign tumors, gene delivery and vaccine. Modeled and modified LNPs will mimic extracellular vesicles (EV) to understand and optimize the uptake by cancer cells.
 

Connaissances requises

• Experience in biotechnology
• Ability to communicate well in writing
• Ease in interacting with students and professionals
• Ability to work, both as a team and independently
• Excellent motivation
• A good academic record."

Programme d'études visé

Doctorat

Domaines de recherche

Santé

Financement

Professor's Scholarship 

Autres informations

Début : Automne 2021

Partenaires impliqués : McGill University, Concordia University